How Long to Cook Pork Tenderloin in Oven At 350?

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By: Tom Valenti


Wondering how long it can take to cook pork tenderloin at 350? If that is the case, I have prepared this post to help you know the exact time you need to cook at this temperature and also how to do it the right way.

What Temperature Should I Cook A Pork Tenderloin At?

When cooking a pork tenderloin, it is recommended to cook it at a temperature of 350 degrees Fahrenheit. This is considered to be the standard temperature. Preheating the oven at this temperature will ensure that the meat is evenly cooked and retains its juiciness. 

How Long Does It Take for A Pork Tenderloin to Cook At 350?

The cook time can vary depending on the size and thickness of the cut. For perfectly cooked, it generally takes about 20 to 30 minutes per pound for the pork tenderloin to cook thoroughly.

So, a small one-pound tenderloin would require around 20-30 minutes, while a larger three-pound cut might take closer to 60-90 minutes. It is essential to use a meat thermometer to verify the internal temperature of the pork reaches 145 degrees Fahrenheit, ensuring it is cooked to a safe temperature while remaining tender and juicy.

Keep in mind that factors such as the oven’s accuracy and that all ovens are different can affect cook times, so it’s recommended to check the pork’s doneness periodically to avoid overcooking.

Once the pork tenderloin is cooked, allow it to rest for a few minutes before slicing and serving, as this will help retain the juices and flavors within the meat and ensure that your pork tenderloin is done. 

How to Properly Prepare A Pork Tenderloin for Cooking?

To properly prepare pork tenderloin for cooking, start by trimming off any excess fat or silver skin from the meat. This will help prevent the cut from becoming tough and chewy. 

Next, marinate the tenderloin in your choice of marinade for at least 30 minutes or up to overnight in the refrigerator. This will infuse the meat with flavor and help to tenderize it.

Before cooking, allow the pork tenderloin to come to room temperature for about 30 minutes. Therefore, properly preparing a pork tenderloin will result in a moist and flavorful cut of meat that is sure to impress your guests.

What You Need to Know Before Cooking Pork Tenderloin?

Before cooking, there are a few important things to keep in mind.

Firstly, it is important to handle the pork tenderloin properly to ensure food safety. Always wash your hands before and after handling raw pork to avoid cross-contamination.

Additionally, make sure to clean any utensils, cutting boards, and surfaces that come into contact with the pork thoroughly.

Secondly, pork tenderloin tends to dry out quickly if overcooked. It is crucial to cook it at the correct temperature and for the right amount of time to retain its tenderness and juiciness. The interior temperature should reach 145°F (63°C) for medium-rare or 160°F (71°C) for medium.

Lastly, marinating the pork tenderloin before cooking can enhance its flavor and tenderness. A simple marinade of olive oil, garlic, herbs, and spices can make a significant difference in the taste.

How Do You Know When Pork Tenderloin Is Done?

Well, it’s all about the touch and the time. You want to aim for a nice medium-rare to medium for the perfect juicy and tender pork. To get that, you can either use a meat thermometer or just rely on your finger and intuition.

If you’re using a thermometer, insert it into the thickest part of the meat and make sure it reads around 145-150°F (63-65°C). Once it reaches that temperature, you can take it off the heat and let it rest for a few minutes to allow the juices to redistribute throughout the meat. 

If you’re going by the touch method, press the meat with your finger. If it feels firm yet yielding, with a slight bounce back, then it’s good to go. Remember, it’s always better to slightly undercook it and let it rest than to overcook it and end up with a dry and tough piece of pork.

What to serve with roasted pork tenderloin?

Well, let me tell you, there are endless options to choose from!

  1. One classic combo is roasted potatoes because they are hearty and filling, plus they soak up all of those tasty pan juices.
  2. If you’re feeling a bit fancy, you could make a creamy mushroom sauce to drizzle over the tenderloin. It adds a luxurious touch and pairs perfectly with the savory flavors of the pork.
  3. Another option is a crunchy green salad with a tangy vinaigrette. It provides a refreshing contrast to the richness of the meat.
  4. Or how about some buttery corn on the cob? It’s a crowd-pleaser and complements the pork beautifully.
  5. If you want to go the lighter route, roasted vegetables like asparagus or Brussels sprouts would be a great choice. 

No matter what you choose, just make sure to have some extra napkins handy because your guests will definitely be coming back for seconds! 

How to Cook Pork Tenderloin in Oven At 350?

EASY Pork Tenderloin In Oven Recipe – So Simple video

Since you already know how long to cook, now start by preheating the oven. It is important to start by preheating your oven to the designated temperature before cooking the tenderloin, as this ensures even cooking throughout. Setting your oven at 350 f is ideal, as this temperature allows the meat to cook fully without drying out. 

To ensure everything is right, below is a comprehensive recipe with the ingredients that you need and step-by-step instructions. Of course, there are several ways to cook a pork tenderloin and the steps below will help you achieve perfect pork tenderloin results. 

How Long to Cook Pork Tenderloin in Oven At 350

Pork Tenderloin Recipe 


  • 1 pork tenderloin approximately 1 to 1.5 pounds
  • 2 tablespoons olive oil
  • 2 teaspoons dried herbs such as thyme, rosemary, or sage
  • 1 teaspoon salt
  • 1/2 teaspoon black pepper
  • 4 garlic cloves minced


  • Set the oven at 350°f (175 degrees Celsius).
  • Pat the pork tenderloin dry using paper towels to remove any excess moisture.
  • In a small bowl, mix together the olive oil, dried herbs, salt, pepper, and minced garlic to make a seasoning mixture.
  • Rub the seasoning mixture all over the pork tenderloin, making sure to coat it evenly.
  • Heat a large oven-safe skillet or a roasting pan over medium-high heat. Once the pan is hot, place the pork tenderloin and sear it on all sides until browned. This step helps to lock in the flavors and juices.
  • Transfer the skillet or roasting pan with the pork tenderloin into the preheated oven.
  • Roast the pork tenderloin for about 20 to 25 minutes, or until it reaches an internal temperature of 145 degrees F.(63 degrees Celsius). It’s essential to use a meat thermometer to accurately check the temperature.
  • Once the pork tenderloin reaches the desired temperature, remove the pork in the oven and tent it loosely with aluminum foil. Let the pork rest for at least 5 to 10 minutes. This allows the juices to redistribute throughout the meat, resulting in juicy and tender pork.
  • After resting, slice the pork tenderloin into thin medallions and serve it warm.


You can pair the pork tenderloin with your favorite side dishes like roasted vegetables, mashed potatoes, or a fresh salad.
Of course, this recipe will be helpful if you want to enjoy delicious and perfectly cooked pork.

What’s the Difference Between Pork Loin and Pork Tenderloin?

Pork loin and pork tenderloin are both cuts of meat that come from the same area of the pig, but they are not the same thing.

Pork Loin is a larger cut of pork that is typically used for roasting. It is a boneless cut of meat that comes from the back of the animal and is known for its tenderness and flavor. 

On the other hand, pork tenderloin is a smaller and more delicate muscle that runs along the backbone. It is a lean cut of meat that is often marinated and grilled or roasted. It is known for its tenderness and is often referred to as the “filet mignon” of pork due to its similar texture and flavor.

Is It Better to Cook A Pork Tenderloin At 350 Or 400?

To ensure delicious pork tenderloin every time, you need to set the right temperatures. The temperature at which it is baked can significantly impact the end result. Generally, a temperature of 350- and 400 degrees F. is recommended to ensure your pork tenderloin is done well. 

Cooking the tenderloin at 350 will result in a slower cooking process and require more time in the oven. This lower temperature allows the heat to penetrate the meat more gradually, resulting in a slightly juicier and more tender pork tenderloin.

On the other hand, cooking the pork tenderloin at 400 degrees will yield faster results and reduce the time it will take. The higher temperature will sear the outside of the tenderloin quickly, sealing in the juices and creating a flavorful crust. It can also help to achieve a slightly crispier texture. 

Ultimately, the decision is between 350- and 400 degrees. depends on personal preference.

If you prefer a more tender and juicy pork tenderloin, opt for 350 degrees and allow for a longer wait time. 

If you prefer a quicker process and a slightly crispier exterior, 400 degrees is the way to go.

Should You Rinse The Pork Tenderloin Before Cooking?

Rinsing pork tenderloin first is a topic of debate among chefs. Some believe that rinsing the meat can help remove any residual bacteria or impurities that might be present. 

However, others argue that rinsing can actually spread these bacteria around the kitchen through splashing water. The truth is that rinsing pork tenderloin is not necessary if you handle and cook the meat safely. It is important to cook pork to a temperature of 145°F, which will kill any harmful bacteria. 

Additionally, proper handling of the meat, such as washing hands, utensils, and surfaces that come into contact with raw pork, can minimize the risk of spreading bacteria.

Ultimately, whether or not to rinse pork tenderloin first is a personal choice. If you feel more comfortable doing so, go ahead, but make sure to follow proper food safety practices to ensure a safe and tasty meal.

Is It Better to Cook Pork Tenderloin Fast or Slow?

When it comes to cooking a pork tenderloin, the method largely depends on personal preference and the desired outcome. Of course, cooking it in the oven is always a choice. 

Cooking it fast, at high heat, can result in a crispy exterior and a tender interior. This method is ideal for those who prefer a less fatty cut of meat and enjoy a slight char on the outside.

On the other hand, slow cooking the pork tenderloin can result in a more tender and juicier final product. This method allows the meat to cook evenly and slowly, allowing it to retain its natural flavor and juices. The slow-cooked tenderloin often has a melt-in-your-mouth texture that is highly sought after. 

Is It Better to Cook the Pork Tenderloin Covered or Uncovered?

Cooking it covered helps to retain moisture and can result in a more tender and juicy pork tenderloin. The covering acts like a sealed environment, trapping the heat and allowing the meat to cook evenly. This method is also ideal for preventing the pork from drying out.

However, if it is uncovered can provide a different experience. By leaving it uncovered, the pork tenderloin has the opportunity to develop a crispy and flavorful crust. The uncovered method allows the outside of the pork to brown and develop a caramelized surface, adding a delicious texture and enhancing the overall taste.

If a tender and moist interior is desired, covering the tenderloin is the way to go. But for those who enjoy a crispy and caramelized exterior, leaving it uncovered can create a delicious result.

Should I Wrap My Pork Tenderloin In Foil?

Nah, you don’t need to go through the hassle of wrapping your pork tenderloin in aluminum foil.

I mean, sure, some folks might argue that it helps retain the moisture and keeps the meat extra tender, but let’s be real here. Foil or no foil, your pork tenderloin is gonna taste delicious.

Plus, who wants to deal with the sticky mess of unwrapping that thing? Just season it up real good with some herbs and spices, pop it in the oven or grill, and let it do its thing.

Trust me, the end result will be a juicy and flavorful piece of meat that you won’t be able to resist. So save yourself the trouble of wrestling with foil and enjoy your pork tenderloin the easy and scrumptious way. 

How Long to Cook Pork Tenderloin in Oven At 350 Per Pound?

The cooking time for pork tenderloin in the oven at 350 degrees Fahrenheit per pound typically ranges between 20 and 30 minutes. It is crucial to cook your pork tenderloin to an internal temperature of 145 degrees Fahrenheit to ensure it is safe to eat.

Lastly, cooking times may vary depending on the size and thickness of the tenderloin, so it is always advisable to check the internal temperature to ensure you get a delicious pork tenderloin. 

What Affect The Time To Cook Pork Tenderloin In Oven At 350?

First off, the size of the tenderloin plays a big role. If it’s a small one, it might only need about 20-25 minutes of cook time. But if you got a bigger piece, then you could be looking at around 30-40 minutes.

Another thing to think about is whether or not you’re using a convection oven. If you are, then the cook time can be reduced by about 25%.

Also, the starting temperature of the tenderloin matters. If it’s been sitting out for a while at room temp, it’ll cook faster compared to if it’s been chilling in the fridge. 


1. Why is my pork tenderloin always dry?

Pork tenderloin might turn out dry if it’s overcooked, as this cut of meat is very lean and doesn’t have much fat to keep it moist. Using high heat for too long can cause the juices to evaporate, leaving the meat dry.

2. Why is my pork tenderloin tough and chewy?

Pork tenderloin can become tough and chewy if it’s overcooked or cooked too quickly. It’s also possible that the meat was not properly tenderized before cooking.

3. How do I make sure my pork tenderloin is tender?

To ensure your pork tenderloin is tender, you should first trim off any excess fat and silverskin. Marinate or brine the meat for a few hours to tenderize it and add flavor. 

Allow the tenderloin to rest for at least 5-10 minutes after cooking before cutting to allow the juices to redistribute.

4. Do you add water to roast pork tenderloin?

While some recipes may call for adding a small amount of liquid (like water, broth, or wine) to the bottom of the roasting pan to help keep the pork moist and to create a sauce or gravy after cooking, it’s not typically necessary when roasting pork tenderloin.

The key to juicy roast pork is to cook it to the right temperature and let it rest after cooking.

5. How to Tell if Pork Tenderloin Is Done Cooking Without a Thermometer?

While a meat thermometer is the most accurate way to determine if pork tenderloin is done, if you don’t have one, you can make a small cut into the thickest part of the tenderloin and check the color. Fully cooked pork should be mostly white with just a hint of pink.

Also, the juices should run clear when you cut into the meat. Remember, the USDA recommends cooking pork to an internal temperature of 145°F, followed by a three-minute rest.


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Tom Valenti

Chef/Owner of both Ouest and ‘Cesca, and the Executive Chef of Le Cirque, Alison on Dominick, and Butterfield 81.

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